I know there are other early church geeks in here so - share your thoughts on the various translations.
I like the Popular Patristics series put out by St. Vladimir's press. The translations are clear and the price is affordable. They do tend to focus more on the later Fathers but they are still quite good. I love John Chrysostom and it is no surprise that these are the best translations of his work. Also one of my favorites is John Damascene's On Divine Images - that one I keep going back to again and again - its absolutely marvelous and inspiring.
The Penguin classics translation is good of the Apostolic Fathers - it is quite clear, readable, and...like me...cheap.
Jurgens is unbeatable for reference, commentary, and breadth of material.
Mike Aquilina's _The Fathers of the Church_ is by far my favorite for devotional purposes. Mike's translation style is packed with the emotion and gets to your heart in short order. I could read this one every day and never tire of it.
Edit: Oh, and of course, there is my favorite website for the Fathers: New Advent