Cancer in Retreat on One Front: Fewer Children Are Dying


NY Times:

Cancer in Retreat on One Front: Fewer Children Are Dying

Children are dying less often from cancer, with substantial declines in all races and age groups, according to a new report from the National Center for Health Statistics.From 1999 to 2014, the overall deaths from childhood cancer fell by 20 percent. The rate among 1- to 19-year-olds went down to 2.28 per 100,000 population, from 2.85. Adolescents 15 to 19 were the most likely to die, but their rate fell by 22 percent.
There were no significant differences in the death rates of white and black children with cancer. Among whites, the rate declined 17 percent; among blacks, 23 percent. The death rate for boys was about 30 percent higher than that for girls.

In 1999, about a third of all cancer deaths among children were caused by leukemia, and a quarter by brain cancer. By 2014, these numbers had reversed — leukemia accounted for 24.9 percent of deaths, and brain cancer 29.9 percent.
Dr. Julia Glade Bender, an associate professor of pediatrics at Columbia University Medical Center, said that the reductions in death rates were the result of lessons learned in clinical trials that had led to small changes in practice.

“Many hope for cancer breakthroughs, or cancer moonshots,” she said. “But it’s a series of well-conceived trials where we’ve studied minor changes in standards of care which add up over decades to substantial gains in survival.”
Doctors are better at prognoses, she added, ramping up treatment for children with high-risk disease while easing off chemotherapy, and its side effects, for children with milder conditions.
Although there are no magic bullets, a few new drugs have been important in improving outcomes. For example, imatinib (brand name Gleevec), originally developed to treat chronic myeloid leukemia in adults, has proved useful in treating acute lymphoblastic leukemia in children.


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