We are free to choose our vocation or direction is life. I think we often come to points in life that are like a fork in the road. At these points we should take time to consider what God may be inviting or asking us to do. We would do better in making our choices this way, and consequently be more likely to recognize what path He wants us to take.
Still, we are free to choose. What we don’t know is what lay ahead for each choice. God can continue to work out our salvation and that of others despite the path we take. Each path will have it’s own challenges, suffering and difficulties. It is what we do with these that really matters.
Now sometimes God does in fact “shut a door in our face.” For example: the company we work for undergoes a merger and as a result we get laid off. Bang, there goes that door. Here is a chance to re-evaluate out place with God and figure out what we might do next. Anyway, that is how it seems to work out for me. I don’t always get it right, but I still land up doing what He really wants me to do, maybe just not in the way originally intended.