So just put a $500-a-head bounty on the damn things and turn the populace loose with shotguns.
I mean, if we could come that close to exterminating bison in the 19th century with black-powder flintlocks, I don’t see a problem with literally wiping out Burmese pythons with what we have available today.
Enact a policy of reptilian genocide. They never should have been brought over here to begin with.
And as for the idiots who turned them loose in the first place, your penance is five hard head-knocks and good swift kick in the pants. Go your way and sin no more.