From Catholic theologian Mark Miravalle, S.T.D.:
"The role of Mary was foreshadowed in the Old Testament. In Genesis, the very first book of the Old Testament, which has been called the ‘protoevangelicum,’ meaning ‘first gospel,’ the ‘woman’ and the ‘serpent’ are put in ‘enmity.’ ‘I will put enmity between you [the serpent] and the woman, and between your seed and her seed; he shall bruise your head, and you shall bruise his heel’ (Gen. 3:15).
“Enmity means a complete and entire mutual opposition. Since the seed of the woman is Christ [who will crush the serpent’s head by his redeeming work], then the woman [in this prophecy] must refer to the Blessed Virgin, who, with her Son, has complete enmity against Satan and against sin” ( Introduction to Mary, Queenship, 1993).