Oooh, great topic! I’m a fandom geek, so I don’t even really need to think about this one.
Mulder & Scully, The Cigarette Smoking Man, and The Lone Gunmen on “The X-Files”
Dr. Greene, Dr. Romano, Dr. Morris on “ER”
Alan Shore & Denny Crane, and Shirley Schmidt on “Boston Legal”
Crowe and Tom Servo on “Mystery Science Theater 3000”
The Huxtable Family on “The Cosby Show”
The Connor Family on “Roseanne”
The Bunker/Stivic Family on “All In The Family”
The Simpson Family, Ned Flanders and Reverend Lovejoy on “The Simpsons”
Dr. Greg House on “House”
Dorothy Zbornack, Rose Nylund, Blanch Deveraux and Sophia Petrillo on “The Golden Girls”
Hmmm…I think that covers most of my fandoms, plus my favorite syndicated shows!